Guest speaker: Prof. Jennifer Potts, Department of Biology, University of York
Staphylococcus aureus can cause human infections associated with significant morbidity and mortality. Our lab has studied repetitive and/or disordered proteins that are attached to the bacterial cell wall and facilitate host cell invasion and/or formation of medical-device associated biofilm infections. These proteins have posed particular challenges that have been addressed using NMR spectroscopy, X-ray crystallography and a range of biophysical techniques. Our studies have revealed novel mechanisms of protein-protein recognition and novel protein structures leading to a better understanding of the function of the staphylococcal surface proteins FnBPA and SasG.